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The blood film examination is done by staining the blood cells with Wright's stain and looking at them under a microscope.

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Blood transfusions are always irradiated to remove white blood cells and thereby reduce the risk of graft-versus-host disease.

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Exposure to tobacco smoke, ionizing radiationor industrial chemicals with the possible exception of diesel does not appear to increase the risk of developing HCL.

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The diagnosis can be confirmed by viewing the cells with a special stain known as TRAP tartrate resistant acid phosphatase.

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It is also possible to definitively diagnose hairy cell leukemia through flow cytometry on blood or bone marrow.

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Am J Hematol.

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Immunophenotypic analysis of peripheral blood by flow cytometry is not widely recognized as a method for diagnosing HCL, perhaps due to the expectation of low yield of neoplastic cells in patients who are characteristically leukopenic.

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Treatment often results in long-term remission.

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The different dosing schedules used with cladribine are approximately equally effective and equally safe.

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Unlike most cancers, treatment success does not depend on treating the disease at an early stage.

It also explains why non-adhered Hairy cell leukemia flow cells, such as those in the bloodstream, disappear during IFN-alpha treatment well before reductions are seen in adhered hairy cells, such as those in the bone marrow and spleen.

Patients will require lifelong monitoring and should be aware that the disease can recur even after decades of good health.

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